老司机直播

'Discover everything there is': 老司机直播's Tak Mak awarded prestigious Gold Leaf Prize for pioneering research

Photo of Tak Mak
The Canadian Institutes of Health Research has named 老司机直播's Tak Mak the recipient of its prestigious Gold Leaf Prize for Discovery, which recognizes groundbreaking health research (photo courtesy of University Health Network)

Tak Mak still recalls his surprise upon learning that Canada鈥檚 Medical Research Council had granted him more money than he requested. It was the early 1980s, and Mak was an assistant professor competing for funds with the other scientists pushing Canada into a global revolution in cell biology.

鈥淚 applied for $50,000 and they gave me $67,000,鈥 says Mak, a  of medical biophysics and immunology at the University of Toronto and a senior scientist at the Princess Margaret Cancer Centre who is renowned for a career that has spanned biochemistry, virology, genetics, cancer metabolism and clinical therapy.

鈥淥ver the years Canada鈥檚 granting agencies have really supported my work in a very paramount way.鈥

That relationship has now come full circle after the Canadian Institutes of Health Research named Mak the recipient of its prestigious Gold Leaf Prize for Discovery, which recognizes groundbreaking health research and comes with $100,000.

The award will support new research, but for Mak it鈥檚 also a recognition that CIHR鈥檚 investments in his work was money well spent. 鈥淲e did all we could to achieve the scientific excellence and innovation CIHR wanted, and to some extent we have fulfilled that intention,鈥 says Mak. 鈥淭hat is gratifying, because when a person or agency is really generous, you don鈥檛 want to disappoint them.鈥

Mak has indeed given Canadians many reasons to be proud.

Mak鈥檚 lab co-discovered the T-cell receptor in 1984 鈥 a finding that fundamentally changed how scientists understood the immune system and led to major advances in T-cell biology, autoimmune disease and immunotherapy. His lab was also one of the first to generate knockout mice 鈥 genetically modified mice 鈥 that enabled scientists worldwide to study the effects of individual genes. And Mak co-founded Agios Pharmaceuticals, whose leukemia drug IDHIFA became the first clinically approved therapy to target cancer metabolism in 2017.

Earlier this year, Mak鈥檚 group used genetics to show that the nervous system and immune system communicate through a molecule called acetylcholine. The discovery confirmed a long-suspected, but poorly understood, link between the two systems, and again opened several new avenues of research.

Mak attributes these and other achievements in part to the co-operation of the Canadian scientific community.

鈥淥ne thing that makes Canada great is congenial and collaborative scientists across the land,鈥 he says. 鈥淎nd looking back at the metamorphosis of our lab from field to field to field, it was in many cases through work with Canadian scientists.鈥

To take two examples: the development of genetically altered mice, Mak says, would not have happened without close collaboration from stem cell biologist and 老司机直播 University Professor Janet Rossant. And when his lab shifted focus from immunology to cancer, Mak says the approach and vision of the late Anthony Pawson, a professor of molecular genetics, was invaluable.

Mak has also benefitted from many talented trainees who have passed through his lab. That group now numbers over 130, and includes a university president, medical school deans and dozens of institute directors and departmental chairs. Mak often visits these former colleagues 鈥 most recently on a trip to the Technical University of Munich this week, where he received an honorary professorship 鈥 and he says that seeing this extended 鈥渇amily鈥 succeed brings great gratification.

鈥淭here鈥檚 no substitute for that. I am reminded of the Indian proverb, 鈥楢ll the flowers of all the tomorrows are in the seeds of today.鈥欌

Mak offers special praise for the mentorship he received as a young researcher, including his time in the lab of Nobel laureate Howard Temin, and his early years in Toronto working with Ernest McCulloch and James Till, who discovered stem cells.

鈥淢cCulloch taught me to think differently, to have original ideas and integrate my thoughts,鈥 Mak says. 鈥淭ill was a staunch, vigorous physicist, who insisted that all results be statistically significant and re-confirmed. The two together made an almost perfect mentorship for me.鈥

Today, that oblique but rigorous approach to science still informs Mak鈥檚 thinking, which increasingly centres on inflammation, another frontier in medical science. Inflammation is essential to the immune system鈥檚 ability to fight germs, but it can create problems that result in autoimmune diseases. Researchers are recognizing the role of inflammation in neuro-degeneration, cardiac disease and many other conditions, and in our ability to fight cancer.

鈥淲e need to understand that important yin and yang,鈥 says Mak. 鈥淲hen the thermostat of inflammation needs to be up, and when certain aspects need to come down 鈥 this is where we need to focus.鈥

Mak is still very engaged with these and other scientific questions. The 鈥減arty,鈥 he notes, is still going strong.

鈥淚 have tremendous gratitude for the support I鈥檝e received from the Canadian scientific community and from CIHR,鈥 he says.

鈥淲hen you鈥檙e a kid you get to play with toys and figure things out, and you鈥檙e not supposed to do that as an adult. But science is like toys for adults, and we get to discover everything there is.鈥

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