Unity Health

Institute of Biomedical Engineering

Leah Cowen

Sinai Health

Sunnybrook Health Sciences Centre

Centre for Addiction and Mental Health

Cell and Systems Biology

Anthropology

Astronomy & Astrophysics

Biochemistry

Chemistry

Computer Science

Ecology and Evolutionary Biology

Hospital for Sick Children

Laboratory Medicine and Pathobiology

Mathematics

Physics

Psychology

UTIAS

Subheadline

From better batteries to preventing memory loss, nearly four dozen projects at ��˾��ֱ�� and its partner hospitals are being supported by the Ontario Research Fund

Researchers in the University of Toronto’s Thermal Management Systems (TMS) Laboratory are working to improve the way battery systems handle heat and develop structural battery pack components. 

“Whether they are being used for electric vehicles or for stationary energy storage systems that reduce strain on the grid, lithium-ion batteries are transforming the way we use electricity,” said Carlos Da Silva, senior research associate at the TMS Lab in the Faculty of Applied Science & Engineering and executive director of ��˾��ֱ��’s Electrification Hub.

“Unfortunately, today’s batteries are still sensitive to temperature: if they get too cold or too hot, it can degrade their performance and even present safety risks. We are working on new technologies that make batteries more resilient to thermal fluctuations.”

The battery-related research is among nearly four dozen projects at ��˾��ֱ�� and its partner hospitals that are receiving almost $35 million in support through the Ontario Research Fund – Research Excellence (ORF-RE) and the Ontario Research Fund – Small Infrastructure (ORF-SIF). (See the full list of projects and their principal researchers below).

"Research at the University of Toronto and at all universities and colleges across Ontario is the foundation of the province’s competitiveness now and in the future,” said Leah Cowen, ��˾��ֱ��’s vice-president, research and innovation, and strategic initiatives.

“This investment protects and advances cutting-edge, made-in-Ontario research in important economic sectors and helps ensure universities can continue to train, attract and retain the world’s top talent."

At ��˾��ֱ�� Engineering’s TMS Lab, researchers led by Cristina Amon, a University Professor in the department of mechanical and industrial engineering, are working on two funded projects. They are developing advanced computational modelling and digital twin methodologies that predict and optimize how heat flows through battery packs. The methodologies are carefully calibrated and validated through industry-relevant experiments in the lab.

Senior Research Associate Carlos Da Silva, left, and University Professor Cristina Amon, right, chat in the Faculty of Applied Science & Engineering's Thermal Management Systems Laboratory (photo by Aaron Demeter)

These methodologies will help battery designers anticipate and prevent thermal management challenges before they arise. It can also enable them to optimize the design and deployment of fire mitigation measures, such as ultra-thin heat barriers, within their battery systems.

The team is also collaborating with Ford Canada and several other companies in the energy storage space. For example, they have worked with Jule (powered by eCAMION) on the development of direct current electric vehicle fast chargers with integrated battery energy storage systems, one of which was recently unveiled on the ��˾��ֱ�� campus.

“We are grateful for this ORF-RE funding, which will accelerate our research and help us further expand our partnerships, ensuring that battery thermal innovations have a seamless transition from the lab to the marketplace,” Amon said.

“As a result of this work, the next generation of batteries will be safer and more resilient than ever before, which is especially important in colder climates like ours here in Ontario.” 

Ontario Research Fund – Research Excellence:

Cristina Amon in the department of mechanical & industrial engineering in the Faculty of Applied Science & Engineering – Powering Ontario’s grid transformation and electric vehicle fast charging with thermally resilient battery energy storage & Next-gen electric vehicle battery systems: Lightweight, thermally performant and fire safe for all climates
Morgan Barense in the department of psychology in the Faculty of Arts & Science – HippoCamera: Digital memory rehabilitation to combat memory loss
Aimy Bazylak in the department of mechanical & industrial engineering in the Faculty of Applied Science and Engineering – RECYCLEAN: Critical minerals recycling & re-manufacturing for the energy transition
Ian Connell at University Health Network and the department of medical biophysics in the Temerty Faculty of Medicine – MRI-compatible innovations for neuromodulation
Simon Graham at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine – Technological innovations for clinical MRI of the brain at 7 tesla
Clinton Groth in the Institute for Aerospace Studies in the Faculty of Applied Science & Engineering – Hydrogen as a sustainable aviation fuel – combustion research to remove impediments to adoption in gas turbine engines
James Kennedy at Centre for Addiction and Mental Health and the department of psychiatry in the Temerty Faculty of Medicine – Clinical utility and enhancements of a pharmacogenomic decision support tool for mental health patients
Shaf Keshavjee at University Health Network and the department of surgery in the Temerty Faculty of Medicine – Advanced solutions to human lung preservation and assessment using artificial intelligence
Aviad Levis in the department of computer science in the Faculty of Arts & Science – AI and quantum enhanced astronomy
JoAnne McLaurin at Sunnybrook Health Sciences Centre and the department of laboratory medicine & pathobiology in the Temerty Faculty of Medicine – Conversion of astrocytes to neurons to treat neurodegenerative diseases of the brain and the eye
R. J. Dwayne Miller in the department of chemistry in the Faculty of Arts & Science – PicoSecond InfraRed Laser (PIRL) “cancer knife” with complete biodiagnostics via spatial imaging mass spectrometry
Javad Mostaghimi in the department of mechanical & industrial engineering in the Faculty of Applied Science & Engineering – A new generation of compact, transportable mass spectrometers for rapid, in-field sample analysi
Xiao Yu (Shirley) Wu in the Leslie Dan Faculty of Pharmacy – Molecular dynamics modeling and screening of excipients for designing amorphous solid dispersion formulations of poorly–soluble drugs

Ontario Research Fund – Small Infrastructure Fund:

Celina Baines in the department of ecology & evolutionary biology in the Faculty of Arts & Science – Impacts of environmental change on organismal movement
Sergio de la Barrera in the department of physics in the Faculty of Arts & Science – Facility for quantum materials and device assembly from atomically thin van der Waals layers
Michelle Bendeck in the department of laboratory medicine & pathobiology in the Temerty Faculty of Medicine – 4D quantitative cardiovascular physiology centre
Laurent Bozec in the department of laboratory medicine & pathobiology in the Temerty Faculty of Medicine – 21st Century challenge for Dentistry: Breaking the cycle of irreversible dental tissue loss
Mark Chiew at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine – Next generation computational MRI for rapid neuroimaging and image-guided therapy
Haissi Cui in the department of chemistry in the Faculty of Arts & Science – A molecule to mouse approach to study the intracellular localization of genetic code interpretation in mammalian cells
Andy Kin On DeVeale at the University Health Network and the Dalla Lana School of Public Health – Sarcopenia and musculoskeletal interactions (sami) collaborative hub
Ali Dolatabadi in the department of mechanical & industrial engineering in the Faculty of Applied Science & Engineering – Advanced cold spray facility
Spencer Freeman at the Hospital for Sick Children and the department of biochemistry in the Temerty Faculty of Medicine – Imaging biophysical determinants of the innate immune response
Liisa Galea at the Centre for Addiction and Mental Health and the Institute of Medical Science in the Temerty Faculty of Medicine – Sex and sex-specific factors influencing brain health across the lifespan
Maged Goubran at Sunnybrook Health Sciences Centre and the department of medical biophysics in the Temerty Faculty of Medicine – AI platform for mapping, tracking and predicting circuit alterations in Alzheimer’s disease
Eitan Grinspun in the departments of computer science and department of mathematics in the Faculty of Arts & Science – A computer graphics perspective on entanglement of slender structures
Levon Halabelian in the Department of Pharmacology and Toxicology in the Temerty Faculty of Medicine – Enabling a high-throughput drug discovery pipeline for targeting disease-related human proteins
Ziqing Hong in the department of physics in the Faculty of Arts & Science – Ultra-sensitive cryogenic detector development for dark matter and neutrino experiments
Eno Hysi at the Unity Health Toronto and the department of medical biophysics in the Temerty Faculty of Medicine – Structural and functional assessments of diabetic skin microvasculature using photoacoustic imaging
Lewis Kay in the department of biochemistry in the Temerty Faculty of Medicine – Helium recovery system for the biomolecular NMR facility
Xiang Li in the department of chemistry and the department of physic in the Faculty of Arts & Science – Real-time multi-faceted probes of quantum materials
Qian Lin in the department of cell & systems biology in the Faculty of Arts & Science – 2p-RAM for whole-brain single-neuron imaging of behaving zebrafish to study neural mechanisms of cognitive behaviours
Xilin Liu in the Edward S. Rogers Sr. department of electrical and computer engineering in the Faculty of Applied Science & Engineering – Integrated circuits for wireless brain implants with multi-modal neural interfaces
Stephen Lye at the Sinai Health System and the department of physiology in the Temerty Faculty of Medicine – Healthy Life Trajectories Initiative (HeLTI) analytics platform
Caitlin Maikawa in the Institute of Biomedical Engineering in the Faculty of Applied Science & Engineering – Biointerfacing materials for drug delivery lab
Emma Master in the department of chemical engineering & applied chemistry in the Faculty of Applied Science & Engineering – Accelerating biomanufacturing innovation through enhanced capacity for scale-up and downstream bioprocess engineering
Roman Melnyk at the Hospital for Sick Children and the department of biochemistry in the Temerty Faculty of Medicine – The H-SCREEN: A platform for high throughput and high content imaging-based small molecule screens for disease modulation
Juan Mena-Parra in the department of astronomy & astrophysics in the Faculty of Arts & Science – An advanced laboratory to enable novel radio telescopes for cosmology and time-domain astrophysics
Seyed Mohamad Moosavi in the department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering – Machine learning for nanoporous materials design
Enid Montague in the department of mechanical & industrial engineering in the Faculty of Applied Science & Engineering – Automation and equity in healthcare laboratory
Michael Norris in the department of biochemistry in the Temerty Faculty of Medicine – Infrastructure for structural and functional virology research hub
Amaya Perez-Brumer in the Dalla Lana School of Public Health – 3P lab: Centering power, privilege and positionality for health equity research
Monica Ramsey in the department of anthropology at the University of Toronto Mississauga – Ramsey Laboratory for Environmental Archaeology (RLEA): How human-environment interactions shaped plant-food
Arneet Saltzman in the department of cell & systems biology in the in the Faculty of Arts & Science – Heterochromatin regulation in development and inheritance
Mina Tadrous in the Leslie Dan Faculty of Pharmacy – Developing a centre for real-world evidence to improve the use of medications for Canadians
Shurui Zhou in the department of electrical & computer engineering in the Faculty of Applied Science & Engineering – Improving collaboration efficiency for fork-based software development
Olena Zhulyn at the Hospital for Sick Children and the department of molecular genetics in the Temerty Faculty of Medicine – Targeting translation for tissue regeneration and repair
Christoph Zrenner at the Centre for Addiction and Mental Health and the Institute of Biomedical Engineering in the Faculty of Applied Science & Engineering – Next-generation real-time closed-loop personalized neurostimulation

Should you eat soy after menopause? ��˾��ֱ�� researchers dispel myth about soy and cancer

rahul.kalvapalle — Wed, 04 Dec 2024 00:53:18 +0000

Should you eat soy after menopause? ��˾��ֱ�� researchers dispel myth about soy and cancer

rahul.kalvapalle Tue, 12/03/2024 - 19:53

Cutline

A study led by researchers at the Temerty Faculty of Medicine's department of nutritional sciences found that soy isoflavones – estrogen-like compounds – had no effect on key markers of estrogen-related cancers (photo by Yagi Studio/Getty Images)

Topic

Breaking Research

Nutritional Sciences

St. Michael's Hospital

Subheadline

“We hope our study will help people feel more comfortable including soy foods in their diet"

A study led by experts at the University of Toronto's Temerty Faculty of Medicine is providing reassuring evidence on consumption of soy foods during postmenopause.

In a systematic review and meta-analysis of 40 trials in over 3,000 participants, ��˾��ֱ�� researchers gathered results on the effects of soy isoflavones – estrogen-like compounds naturally found in plants – on biological outcomes related to risk of endometrial and other female-related cancers.

Their results, published in Advances in Nutrition, found that isoflavones had no effect on key markers of estrogen-related cancers, supporting the safety of soy as a food as well as potential therapy.

“The risk of cardiovascular disease increases substantially as women* go through menopause, so soy can offer dual benefits during this particular phase of life,” says the study’s senior author Laura Chiavaroli, an assistant professor in Temerty's department of nutritional sciences and affiliate scientist at the Li Ka Shing Knowledge Institute at St. Michael’s Hospital, Unity Health Toronto.

Assistant Professor Laura Chiavaroli (left) and PhD student Gabrielle Viscardi (supplied images)

Yet, Chiavaroli notes many people are hesitant to eat soy foods because they contain isoflavones, which have a similar structure to estrogen. In animal studies, large doses of isoflavones have been linked to a higher risk of cancer.

“Something we hear very often is that people have a lot of concern about consuming soy because there are so many conflicting messages out there,” says Gabrielle Viscardi, a second-year PhD student in the department of nutritional sciences and the study’s lead author.

This is despite the fact that several health advocacy groups, including the Canadian Cardiovascular Society, already recommend soy foods as part of a healthy diet. Health Canada and the U.S. Food and Drug Administration have both recognized soy – a high-quality and complete source of protein – as effective in reducing the risk of heart disease

Soy foods have also been shown to alleviate hot flashes associated with menopause, which affect many women and impact their quality of life.

The trials considered for the ��˾��ֱ�� study followed postmenopausal women from around the world who had consumed either soy isoflavones or a non-isoflavone control for at least three months.

The researchers concluded that consumption of soy isoflavones did not affect the four key estrogen-related markers, namely: thickness of uterus lining, vaginal maturation index (a measure of estrogen status) and levels of circulating estrogen and follicle-stimulating hormone.

Their findings support the idea that soy isoflavones behave differently from human estrogen, particularly when it comes to cancers that depend on estrogen to develop. “We have estrogen receptors throughout our bodies but, contrary to the hormone estrogen, isoflavones from soy don’t bind to all the estrogen receptors equally,” says Viscardi, who is also a registered dietitian. “That’s why we see a beneficial effect on the cardiovascular system and no effect on the female reproductive system.”

This difference in biological activity explains why soy isoflavones have been considered as a possible alternative to hormone replacement therapy (HRT), which is used to treat menopause symptoms by replacing the estrogen that the body stops producing during this period.

Chiavaroli notes some people don’t want to take HRTs and are seeking alternative options.

Further, HRTs may also not be a good option for people at an increased risk of estrogen-sensitive cancers like breast cancer, as well as those with a history of heart disease and stroke. For these individuals, consuming soy foods as part of a balanced diet could help manage their menopausal symptoms while also reducing the risk of cardiovascular disease.

Chiavaroli says the study's findings also align with Health Canada’s dietary guidelines that encourage people to choose plant-based proteins more often, a move that would also convey benefits for the environment.

“We hope our study will help people feel more comfortable including soy foods in their diet without being concerned that it’s going to increase their risk of estrogen-dependent cancer,” says Chiavaroli.

The study was funded by the United Soybean Board (U.S. Department of Agriculture) and the Canadian Institutes of Health Research through the Canada-wide Human Nutrition Trialists’ Network.

* Although menopause is sex-specific, the study retains use of the term "women" as it is used conventionally in studies and guidelines on menopause

AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study

Christopher.Sorensen — Mon, 23 Sep 2024 16:50:13 +0000

AI tool reduces risk of unexpected hospital deaths by 26 per cent: Study

Christopher.Sorensen Mon, 09/23/2024 - 12:50

Cutline

(photo by Tempura/Getty Images)

Adam Miller

Topic

Artificial Intelligence

St. Michael's Hospital

Subheadline

CHARTWatch, an artificial intelligence early warning system developed at Unity Health Toronto, alerts physicians when hospital patients face a high risk of unexpected death or transfer to an ICU

A new study by Toronto researchers evaluates the use of CHARTWatch, an artificial intelligence early warning system developed at Unity Health Toronto that monitors hospitalized patients in real-time, identifies those at high risk of unexpected death or transfer to an intensive care unit, and alerts doctors and nurses to intervene early.

The study, published in the Canadian Medical Association Journal, shows a 26 per cent reduction in unanticipated mortality after the tool was implemented in the general internal medicine ward of Unity Health Toronto’s St. Michael’s Hospital.

“As AI tools are increasingly being used in medicine, it is important that they are evaluated carefully to ensure that they are safe and effective,” says lead author Amol Verma, general internist at Unity Health and professor in the department of medicine in the University of Toronto’s Temerty Faculty of Medicine who led the development and implementation of CHARTWatch.

Amol Verma (L) and Muhammad Mamdani (supplied images)

“Our findings suggest that AI-based early warning systems are promising for reducing unexpected deaths in hospitals.”

One of the primary sources of unplanned admission to the ICU is the unexpected deterioration of hospitalized patients, which prompted the research team to develop this AI tool and study its effectiveness.

“This important study evaluates the outcomes associated with the complex deployment of the entire AI solution, which is critical to understanding the real-world impacts of this promising technology,” says study co-author Muhammad Mamdani, vice president of data science and advanced analytics at Unity Health and director of ��˾��ֱ��’s Temerty Centre for Artificial Intelligence Research and Education in Medicine.

“We hope other institutions can learn from and improve upon Unity Health Toronto’s experiences to benefit the patients they serve.”

The study analyzed data from 13,649 patients aged 55 to 80 years old admitted to the general internal medicine unit (9,626 in the pre-intervention period and 4,023 using CHARTWatch) and 8,470 admitted to subspeciality units that did not use CHARTWatch.

Helping to prioritize patient needs

“The CHARTWatch project started at Unity Health when we asked patients, clinicians, hospital leaders, what would you want to use artificial intelligence for? If you could predict one thing that AI would tell you, what should that be?” says Verma, who is also the Temerty Professor of AI Research and Education in Medicine.

“And one of the leading priorities of everyone was to be able to predict in advance which patients might become so sick in hospital that they need ICU or might die.”

During the 19-month-long intervention period, 482 patients in the general internal medicine became high-risk, compared with 1,656 patients who became high risk in the 43-month-long pre-intervention period. There were also fewer non-palliative deaths in the CHARTWatch group than in the pre-intervention group (1.6 per cent versus 2.1 per cent).

“If I were a patient, I would be so relieved to know that we have this kind of system,” said co-author Yuna Lee, division head and general internist at St. Michael’s and professor in the department of medicine at ��˾��ֱ��.

“So, when the patient gets a high-risk alert, they’re going to be assessed by senior staff right away. Also, they’re going to have quite close monitoring by nursing staff, so they check on them every one to two hours.”

Expanding the impact of CHARTWatch

CHARTWatch inputs more than 100 aspects of a patient’s medical history and current health status that are routinely stored in the hospital’s electronic medical record. It analyzes the interactions between these inputs and how they change over time. With that information, it’s able to categorize each patient by their risk for deterioration and send an alert to prioritize treatment.

The study is one of the first to evaluate how CHARTWatch can benefit hospital patients in Canada and shows the potential real-world impact of AI on the health-care sector. Damian Jankowicz, Unity Health’s vice-president and chief information and AI officer, says he hopes AI tools such as CHARTWatch will continue to have a profound impact on patients.

“Hopefully with reduced administrative burden on our providers, they will have more time to spend with our patients and really focus on the patient needs,” he says.

“I hope that AI will be able to distill the incredible amounts of information that’s coming at our clinicians into important components and really bring their clinical judgment to the forefront.”

This story first was first published by Unity Health.

��˾��ֱ�� community members recognized with Order of Canada

bresgead — Thu, 04 Jul 2024 16:49:13 +0000

��˾��ֱ�� community members recognized with Order of Canada

bresgead Thu, 07/04/2024 - 12:49

Cutline

(photo by Sgt Johanie Maheu, Rideau Hall, OSGG-BSGG)

Adina Bresge

Topic

Institute of Health Policy Management and Evaluation

��˾��ֱ��

Chemistry

Hospital for Sick Children

Faculty of Music

Order of Canada

Political Science

St. Michael's College

University College

Institutional Strategic Initiatives

Victoria College

Subheadline

"The Order of Canada recognizes individuals who have made positive and lasting impacts on communities here in Canada or who have brought honour to our country abroad"

An innovator in chemical catalyst development. A global leader in cardiac surgery and care. And a public health expert who led the rollout of Canada’s first colon cancer screening program.

These are a few members of the University of Toronto community who were recently honoured with appointments or promotions within the Order of Canada.

The Governor General recently announced 83 new appointments to the Order of Canada, including two promotions within the Order.

They include Doug Stephan, a University Professor of chemistry in the Faculty of Arts & Science; Lee Errett, a professor in the Temerty Faculty of Medicine’s department of surgery, and Linda Rabeneck, a health executive and professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health.

Established in 1967, the Order of Canada is one of the country’s highest honours, recognizing extraordinary contributions across all sectors of society.

“The Order of Canada recognizes individuals who have made positive and lasting impacts on communities here in Canada or who have brought honour to our country abroad,” Gov. Gen. Mary Simon said in a statement.

Here is a list of ��˾��ֱ�� faculty, alumni and supporters who were appointed to, or promoted within, the Order of Canada in the latest round of honourees.

Current and former faculty

Edward Cole, a staff nephrologist at Toronto General Hospital and professor in the Temerty Faculty of Medicine’s department of medicine, was named a Member of the Order for his dedication to advancing and delivering care to people living with kidney disease, his instrumental role in establishing a globally impactful kidney-paired donation program and his leadership as former physician-in-chief at the University Health Network.

Lee Errett, a professor in the Temerty Faculty of Medicine’s department of surgery, was appointed a Member of the Order for his transformative leadership in cardiac research and care, including his role in establishing St. Michael’s Hospital as a world-class centre for cardiac surgery, his dedication to educating future medical leaders and providing care in underserved areas worldwide.

Franklyn Griffiths, a professor emeritus and George Ignatieff Chair Emeritus of Peace and Conflict Studies in the department of political science in the Faculty of Arts & Science, was appointed a Member of the Order for his scholarship on Russian affairs which has advanced the Western world’s understanding of Soviet politics. An expert in Arctic international relations, Griffiths helped create the Arctic Council and pushed for Indigenous voices to play a central role in the council’s workings.

Beverley Johnston, an internationally renowned percussionist who is an adjunct professor in the Faculty of Music, was appointed an Officer of the Order for her work developing and promoting Canadian music to audiences around the world. Working in a male-dominated field, Johnston’s unconventional performances combine classical transcriptions, contemporary music and an element of theatre.

Daphne Maurer, a professor emeritus of psychology, neuroscience and behaviour at McMaster University who holds a status appointment at ��˾��ֱ��’s Institute of Health Policy Management and Evaluation in the Dalla Lana School of Public Health, was appointed an Officer of the Order for her research on visual and cognitive development in early childhood.

Linda Rabeneck, a gastroenterologist, health executive and professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health, was named a Member of the Order for her leadership in colorectal cancer screening and prevention. Formerly the director of the Division of Gastroenterology at ��˾��ֱ��, she led the rollout of ColonCancerCheck, Canada’s first province-wide screening program.

Stephen Randall, who earned his master's degree and doctorate at ��˾��ֱ�� and taught at the university from 1971 to 1974, was named a Member of the Order for his academic contributions and advisory role in international relations. A professor emeritus at the University of Calgary, Randall’s expertise in myriad issues affecting the United States and Latin America, notably Colombia, has informed Canada’s foreign policy.

Bibudhendra Sarkar, senior scientist emeritus at the Research Institute of the Hospital for Sick Children and professor emeritus at ��˾��ֱ��’s department of biochemistry in the Temerty Faculty of Medicine, was named a Member of the Order for his achievements in advancing medical research in Canada and abroad. He discovered a novel treatment for patients with Menkes disease, a rare genetic condition, and led international efforts in South and Southeast Asia to address public health crises from contaminated groundwater.

Jonathan Scott Rose, a professor in the Edward S. Rogers Sr. department of electrical and computer engineering in the Faculty of Applied Science & Engineering, was named a Member of the Order for his pioneering work in architecture and software used in field-programmable gate arrays. Rose served as the chair of the department from 2004 to 2009 and received his PhD degree in electrical engineering from ��˾��ֱ�� in 1986.

Doug Stephan, a University Professor in the department of chemistry in the Faculty of Arts & Science, was named an Officer of the Order in recognition his world-leading research in inorganic and organometallic chemistry. His many achievements include discovering – and commercializing – a new class of catalysts that is now used in one of the largest chemical manufacturing facilities in the world. He also achieved global renown for founding the field of “Frustrated Lewis Pair” chemistry.

��˾��ֱ�� and friends

Sleight-of-hand artist David Ben, who graduated from University College in 1983, was named a Member of the Order for his four decades of dedication to the exploration, development and preservation of magic, including penning several books on the subject and co-founding the Magicana organization.

William Fox, a research fellow and adjunct professor at Trent University who earned his honours bachelor of arts and master of arts in archeology at ��˾��ֱ��, was named a Member of the Order for his distinguished contributions to Canadian archeology, his leadership in the Ontario Archaeological Society, and his steadfast advocacy for the involvement of Indigenous communities in preserving their material heritage.

Martha Friendly, who founded the Childcare Resource and Research Unit at ��˾��ֱ��’s Centre for Urban and Community Studies in the early 1980s, was appointed an Officer of the Order for her work with the now-independent non-profit and her advocacy for accessible, publicly funded early childhood education and care, and women’s equality.

Rosemary Ganley, a writer, activist, teacher and an alumna of St. Michael’s College, was named a Member of the Order for her lifelong advocacy for human rights, gender equity, and social justice, including co-founding Jamaican Self Help, an organization of Canadians working to support the development of healthy Jamaican communities.

Arnie Gelbart, a member of the Chancellors’ Circle of Benefactors, was named a Member of the Order for his decades-long leadership in independent film and television in his role as founder, executive producer and CEO of Galafilm Productions Inc.

Judy Kent was named a Member of the Order for championing sport as a catalyst for social change, her advocacy for gender equality and inclusion and her leadership in international support. Among her achievements: She was the first woman to serve as both president of Commonwealth Sport Canada and Canada’s chef de mission for the Commonwealth Games, and her paper on sport for international development laid the foundation for the SportWORKS program.

James David Meekison, with a 45-year career spanning investment banking, cable television and private equity, was named a Member of the Order for his extensive philanthropy. The Jim Meekison and Carolyn Keystone Foundation supported ��˾��ֱ��’s Leslie Dan Faculty of Pharmacy’s efforts to launch the Discovery Pharmacy on the St. George campus.

Michael Perley, a ��˾��ֱ�� alumnus who completed a master’s degree in French language and literature, was named a Member of the Order for his lifelong dedication to tackling environmental and health challenges. He has been an advocate for tighter tobacco control laws, reducing second-hand smoke exposure and has led coalitions on acid rain and air pollution.

Dan Poenaru, a pediatric surgeon and professor at McGill University who earned two degrees at ��˾��ֱ��, was named a Member of the Order for his contributions to pediatric surgery in Africa, including establishing a surgical unit and training program in Kenya, co-founding three medical schools and leading initiatives for children's surgery globally.

Vaira Vike-Freiberga, an alumna of Victoria College and the first woman to serve as Latvia’s president, was named an honorary Officer of the Order for her work enriching Canada-Latvia relations and for reflecting Canadian values abroad.

– with files from Mariam Matti and Rahul Kalvapalle

Canadian Hub for Health Intelligence and Innovation in Infectious Diseases awarded $72 million

Christopher.Sorensen — Mon, 06 May 2024 16:07:51 +0000

Canadian Hub for Health Intelligence and Innovation in Infectious Diseases awarded $72 million

Christopher.Sorensen Mon, 05/06/2024 - 12:07

Cutline

(photo by Nick Iwanyshyn)

Topic

Leah Cowen

PRiME

Sinai Health

Chemistry

Subheadline

Federal funding will be used to strengthen talent development and health intelligence in order to respond to emerging health threats

Four research programs in the Canadian Hub for Health Intelligence and Innovation in Infectious Diseases (HI³) have received $72 million in federal funding from the Canada Biomedical Research Fund (CBRF) and Biomedical Research Infrastructure Fund (BRIF), bolstering the country’s biomanufacturing capacity and readiness to respond to emerging health threats.

Support for HI³ and the four funded research programs through the CBRF and BRIF is part of a larger investment in Canada’s Biomanufacturing and Life Sciences Strategy. The strategy aims to grow a strong, competitive domestic life sciences sector with cutting-edge biomanufacturing capabilities and to improve the country’s ability to respond to future health challenges.

HI³ – a coalition of 87 academic, hospital, research networks, industry, government, not-for-profit and community partners – was one of five national hubs established in March 2023 with CBRF funding.

Together, the four awarded programs will provide critical health intelligence data to guide the co-development of health threat surveillance platforms and next-generation precision interventions by the hub’s academic and industry partners, while building a highly skilled workforce to support Canada’s growing biomanufacturing and life sciences sector.

“Congratulations to HI³ and the collaborative teams behind these CBRF-funded programs. These four programs leverage the tremendous expertise of the University of Toronto's researchers and our partners in academia, hospitals, industry and other sectors to develop the talent, tools and data required to be at the forefront of emerging health threats,” said Leah Cowen, ��˾��ֱ��’s vice-president, research and innovation, and strategic initiatives.

“On behalf of the University of Toronto and HI³, I thank the government of Canada for its investment in building a strong domestic life sciences sector ready to take on the health challenges of today and tomorrow.”

One of the CBRF-funded programs is the Biomanufacturing Hub Network (BioHubNet), an immersive talent development program based at ��˾��ֱ�� and led by University Professor Molly Shoichet along with Darius Rackus, an assistant professor of chemistry and biology at Toronto Metropolitan University, and Gilbert Walker, a professor of chemistry at ��˾��ֱ��.

“With world-leading scientists and researchers established across Canadian leading research institutions, Canada is home to a competitive and robust biomanufacturing and life sciences sector. We made a promise to Canadians that we would rebuild the domestic sector,” said François-Philippe Champagne, Canada’s minister of innovation, science and industry. “With this investment, our government is delivering on this promise by supporting the excellent innovations, collaborations and infrastructures necessary to rapidly respond to future public health threats and keep Canadians safe.”

The predicted supply of biomanufacturing workers is only enough to fill one-quarter of the positions that will be needed in the sector by 2029, according to a 2021 report from BioTalent Canada.

To address the shortage, BioHubNet will leverage its 26 industry and training partners – which include multinational and homegrown biotechnology companies, as well as five Ontario colleges and nearly $19 million in funding from CBRF – to develop a range of training programs and curricula that provide experiential, hands-on learning to graduate students, postdoctoral fellows and others who are ready to transition to industry.

The program will also outfit entrepreneurs with the skills and resources they need to commercialize their lab-based innovations, further strengthening the translational pipeline. Over the next four years, BioHubNet will produce close to 1,000 highly skilled workers through micro-credential courses, industry internships, academic exchange placements and entrepreneurial training.

A central tenet underlying all BioHubNet’s offerings is a commitment to create more equitable and inclusive participation in the biomanufacturing and life sciences sectors through intentional recruitment and active support for trainees from under-represented groups.

“Canada’s future as a leader in bio-innovation depends on having highly qualified workers, yet the sector is predicted to face severe workforce shortages in the coming years,” says Shoichet, who is the Michael E Charles Professor in Chemical Engineering at ��˾��ֱ�� and scientific director of PRiME Next-Generation Precision Medicine, a ��˾��ֱ�� institutional strategic initiative based at the Leslie Dan Faculty of Pharmacy.

“By expanding the pipeline of skilled research talent in Canada, BioHubNet will accelerate the translation of promising discoveries from bench to market and ensure that this country’s biomanufacturing sector continues to grow and attract further international investment.”

In addition to BioHubNet, three other research programs were also funded:

The Integrated Network for the Surveillance of Pathogens: Increasing Resilience and capacity in Canada’s pandemic response (INSPIRE) based at the University of Windsor. Co-led by Windsor professor Mike McKay and University of Guelph professor Lawrence Goodridge, the INSPIRE program leverages community-level wastewater surveillance data, infrastructure and expertise to monitor the arrival and spread of infectious threats. The program also received infrastructure funding from BRIF to implement technologies and processes across its network that will streamline wastewater surveillance efforts to be more rapid, agile and sensitive. Importantly, these infrastructure supports will expand wastewater monitoring capacity in northern Ontario and at the Windsor-Detroit border to strengthen supply chains.
The Prepare, React, Collect, Innovate, Share and Engage (PRECISE) Diagnostic Platform, based at Sinai Health and co-led by Jennie Johnstone and Anne-Claude Gingras – who are both faculty members in ��˾��ֱ��’s Faculty of Medicine – will advance a comprehensive, streamlined approach for responding to emerging threats by driving the timely development of rapid diagnostic tools that will scale up testing capacity and reduce reliance on global supply chains.
The Pandemic Preparedness Engaging Primary Care and Emergency Departments (PREPARED) program, based at Unity Health Toronto and led by Andrew Pinto, who is a faculty member in the Temerty Faculty of Medicine, aims to engage primary care clinics and emergency departments across the country to enhance disease monitoring, improve patient care and health system efficiency, accelerate the development of medical countermeasures and boost recruitment to clinical trials.

All four research programs reflect the hub’s extensive network of nearly 100 partners from academia, hospital, industry, public and other sectors. The programs leverage the collective resources and expertise of this network, including ��˾��ֱ��’s position as a global leader in artificial intelligence, data, life sciences and engineering, and the Toronto Academic Health Sciences Network’s strong track record of clinical impact and health-care innovation.

“Our goal at HI³ is to advance mission-driven, team-based science that will help Canada be more prepared, resilient and independent in the face of emerging health threats,” said Jen Gommerman, co-director of HI³ and a professor of immunology in ��˾��ֱ��’s Temerty Faculty of Medicine.

“As we support and grow these four research programs, we will continue to work closely with our hub partners and with our counterparts across the country to ensure that we have the capacity and resources needed to respond in a co-ordinated, effective and equitable manner.”

What Now? AI, Episode 3: Innovation for Good

Christopher.Sorensen — Thu, 18 Apr 2024 20:47:11 +0000

What Now? AI, Episode 3: Innovation for Good Christopher.Sorensen Thu, 04/18/2024 - 16:47

Topic

Schwartz Reisman Institute for Technology and Society

What Now? AI

Artificial Intelligence

Computer Science

Faculty of Information

Startups

��˾��ֱ�� Mississauga

While the news headlines about AI often focus on dangers and risks, the potential for life-saving innovation in fields such as health care is huge.

In the third episode of What Now? AI, co-hosts Beth Coleman and Rahul Krishnan of the University of Toronto are joined by experts Christine Allen and Andrew Pinto to discuss AI’s potential to advance drug development and dramatically improve primary care.

Listen to episode three on Apple, Spotify, SoundCloud, iHeartRadio and Amazon. Watch episode three on YouTube.

Allen, a professor in ��˾��ֱ��’s Leslie Dan Faculty of Pharmacy and an expert in drug formulation and development, co-founded Intrepid Labs Inc. with Alán Aspuru-Guzik, a professor in the departments of chemistry and computer science in ��˾��ֱ��’s Faculty of Arts & Science.

One of the first startups to emerge from the Acceleration Consortium at ��˾��ֱ��, Intrepid Labs is accelerating pharmaceutical drug development through the integration of AI, automation and advanced computing.

“It’s this concept of using AI to explore the unexplored,” Allen says.

“What if that formulation could really transform the properties and performance of your drug is one of those unexplored formulations. That will then take that drug through clinical development smoothly and get it to patients faster, which is really the goal.”

Meanwhile, Pinto, a family physician at St. Michael’s Hospital and director of the Upstream Lab, Unity Health Toronto, focuses his research on addressing the social determinants of health by running clinical trials of interventions and using AI tools for surveillance of respiratory illness.

“When we started to do this work around AI in primary care, we wanted to be directed by primary care providers and patients,” says Pinto, an associate professor in the department of family and community medicine in ��˾��ֱ��’s Temerty Faculty of Medicine and at the Dalla Lana School of Public Health.

Reducing health-care inequities is top of mind for Pinto. His lab focuses on implementing AI to prioritize community engagement and bridge socioeconomic gaps to mitigate biases.

“We’re using these tools to look at all of the patients in a population and then focus our attention on the people who need it most.”

About the hosts:

Beth Coleman is an associate professor at ��˾��ֱ�� Mississauga’s Institute of Communication, Culture, Information and Technology and the Faculty of Information. She is also a research lead on AI policy and praxis at the Schwartz Reisman Institute for Technology and Society. Coleman authored Reality Was Whatever Happened: Octavia Butler AI and Other Possible Worlds using art and generative AI.

Rahul Krishnan is an assistant professor in ��˾��ֱ��’s department of computer science in the Faculty of Arts & Science and department of laboratory medicine and pathobiology in the Temerty Faculty of Medicine. He is a Canada CIFAR Chair at the Vector Institute, a faculty affiliate at the Schwartz Reisman Institute for Technology and Society and a faculty member at the Temerty Centre for AI Research and Education in Medicine (T-CAIREM).

Heart-on-a-chip model used to glean insights into COVID-19-induced heart inflammation

Christopher.Sorensen — Mon, 08 Apr 2024 19:06:23 +0000

Heart-on-a-chip model used to glean insights into COVID-19-induced heart inflammation

Christopher.Sorensen Mon, 04/08/2024 - 15:06

Cutline

Researchers worked in the Toronto High Containment Facility at ��˾��ֱ�� to examine the effects of COVID-19 on heart inflammation (photo by Lisa Lightbourn)

Institute of Biomedical Engineering

Topic

Breaking Research

��˾��ֱ��

Subheadline

Researcher dedicates study to her late grandmother, who died from COVID-19-induced heart failure

Researchers at the University of Toronto and its partner hospitals have created a unique heart-on-a-chip model that is helping untangle the causes of COVID-19-induced heart inflammation and uncover strategies to reduce its impact.

While COVID-19 is primarily a respiratory infection, clinicians and researchers are increasingly aware of the virus’s effects on other organs – including the heart. Data from the U.S. Centers for Disease Control and Prevention shows patients hospitalized with COVID-19 between March 2020 and January 2021 had 15 times higher risk for developing myocarditis, or inflammation of the heart muscle, compared to patients without COVID-19.

But the biology behind the association between SARS-CoV-2 infection and heart inflammation had remained unclear – in part because there have not been good models with which to study infection-related heart inflammation.

“Conventionally, people grow heart cells in a 2D setting and then expose it to SARS-CoV-2 to see how the virus damages the heart. But that’s not actually what happens in our body,” says Rick Lu, a PhD graduate from ��˾��ֱ��’s Institute for Biomedical Engineering who is currently a postdoctoral researcher at ��˾��ֱ��’s Leslie Dan Faculty of Pharmacy.

Lu is the first author of a new study published in Science Advances that describes a miniature 3D heart-on-a-chip model that more accurately captures the impact of SARS-CoV-2 infection and its associated immune response on cardiac dysfunction.

The first-of-its-kind model builds on previous work led by Milica Radisic, Lu’s PhD adviser, a senior scientist at University Health Network and a ��˾��ֱ�� professor of biomedical engineering. The approach uses a lab-made network of blood vessels surrounded by heart tissues grown from stem cells to mimic a real human heart with its tangle of vessels going in and out.

From left to right: Researchers Milica Radisic, Rick Lu and Claudia dos Santos (supplied images)

To examine the effects of COVID-19 on heart inflammation, Lu and his colleagues first had to adapt their model to work in the Toronto High Containment Facility, a specialized lab that allows researchers to study high-risk pathogens like SARS-CoV-2 in a safe and secure way.

“This work would simply not be possible without the Toronto High Containment Facility,” says Radisic, who holds the Canada Research Chair in Organ-on-a-Chip Engineering.

In the high containment lab, the researchers added live virus and immune cells to the blood vessels and allowed them to flow through their mini hearts-on-a-chip, replicating the immune response that happens after a SARS-CoV-2 infection. They found that the combination of SARS-CoV-2 and immune cells reduced the heart’s ability to contract and pump. To understand why, the researchers turned to mitochondria, the tiny energy storehouses that power the muscle’s beating movements. They showed that SARS-CoV-2 infection led to loss of mitochondria and a release of mitochondrial DNA from the heart cells into the nutrient broth used to grow the organoids.

Working with Claudia dos Santos, a scientist and critical care doctor at Unity Health Toronto, associate professor of medicine and Pitts Research Chair in Acute Care and Emergency Medicine at ��˾��ֱ��’s Temerty Faculty of Medicine, the researchers then asked whether the presence of freely circulating mitochondrial DNA is also seen in patients experiencing COVID-19-induced heart complications.

They analyzed blood samples from patients with and without COVID-19 and found nearly two-and-a-half times higher levels of mitochondrial DNA in patients who were COVID-19-positive. Their findings point to mitochondrial DNA levels as a powerful predictor of a person’s risk of experiencing cardiac problems after SARS-CoV-2 infection.

The team also showed that a new type of cell-based therapy called exosomes – little cargo vessels that bubble off cells – could reduce inflammation and mitochondria loss, as well as improve heart function, after SARS-CoV-2 infection, highlighting their potential to repair COVID-19-associated heart damage.

By integrating blood vessels and immune cells, Lu hopes that the innovative heart-on-a-chip model can help researchers and clinicians understand and identify treatment strategies for other infection-related heart conditions.

“The good thing about our system is that it’s readily adaptable to any kind of infectious disease,” says Lu. “The other benefit is that we don’t have to rely as much on animal models. Since we’re already using human-derived cells, the clinical translatability is much higher.”

As a next step, Radisic’s group plans to use the miniature organs to uncover why males are more likely than females to experience COVID-19-associated heart complications and to examine the cardiac issues commonly seen in people with long COVID-19.

Radisic says the motivation for this work was deeply personal. She dedicated the study to her late grandmother who died from COVID-19-induced heart failure after six weeks in the intensive care unit.

“The feeling of helplessness is rather profound when a loved one is dying,” she says. “As scientists, we can take small steps toward new cures so that other people do not meet the same fate. For me, this work meant overcoming the feeling of helplessness.”

The work was supported by investments from the Canada Foundation for Innovation and the creation of the ��˾��ֱ�� COVID-19 biobank and the Precision Medicine in Critical Care (PREDICT) Biobank at Unity Health Toronto – and by the contributions of patients and families that donated biological samples, making significant advances in research possible.

How will AI change our world? ��˾��ֱ�� podcast explores technology’s impact on society

Christopher.Sorensen — Thu, 04 Apr 2024 15:17:45 +0000

How will AI change our world? ��˾��ֱ�� podcast explores technology’s impact on society

Christopher.Sorensen Thu, 04/04/2024 - 11:17

Mariam Matti

Topic

Schwartz Reisman Institute for Technology and Society

What Now? AI

��˾��ֱ��

Artificial Intelligence

CIFAR

Computer Science

Faculty of Information

Faculty of Law

Geoffrey Hinton

Startups

��˾��ֱ�� Mississauga

Vector Institute

Subheadline

In What Now? AI, hosts Beth Coleman and Rahul Krishnan explore – and demystify – artificial intelligence and its impact on society with the help of leading experts

Rapid advances in artificial intelligence are posing profound questions about the future – and about us.

Can we ensure safety and alignment within AI systems? How might AI forever transform fields like health care? What ripple effects could AI have on jobs and livelihoods, including in creative industries?

University of Toronto researchers Beth Coleman and Rahul Krishnan explore – and demystify – these and other topics by tapping into the knowledge of leading AI experts in What Now? AI, a new ��˾��ֱ�� podcast that launches this week.

It can be found on Apple, Spotify, Soundcloud, iHeartRadio and Amazon.

An associate professor at ��˾��ֱ�� Mississauga’s Institute of Communication, Culture, Information and Technology and the Faculty of Information, Coleman says she hopes the episodes help audiences make sense of new AI tools and systems by cutting through “all the noisiness and controversy that has taken over the headlines.”

“It can be complex and technical, but it’s also social,” says Coleman, a research lead on AI policy and praxis at the Schwartz Reisman Institute for Technology & Society.

“What we do with AI makes a difference and more people need to be able to share that knowledge.”

Coleman’s own research centres around technology and society with a focus on data and cities, AI and policy, and generative arts. Inspired by Octavia Butler’s 1980 Xenogenesis trilogy, Coleman authored Reality Was Whatever Happened: Octavia Butler AI and Other Possible Worlds using art and generative AI.

Krishnan, meanwhile, is an assistant professor in ��˾��ֱ��’s department of computer science in the Faculty of Arts & Science and department of laboratory medicine and pathobiology in the Temerty Faculty of Medicine. A Canada CIFAR AI Chair at the Vector Institute and Canada Research Chair in computational medicine, Krishnan and his team focus on teaching neural networks about causality, building deep learning models that analyze cause and effect from data.

“I’m excited to co-host this podcast to explore and demystify for a broader audience AI through the lens of an accomplished and diverse set of experts,” says Krishnan, who is also a faculty affiliate at the Schwartz Reisman Institute for Technology and Society and a faculty member at the Temerty Centre for AI Research and Education in Medicine (T-CAIREM).

What Now? AI picks up where the conversation started last year by Geoffrey Hinton, the cognitive psychologist and University Professor emeritus of computer science who is known as the “Godfather of AI.” After a lifetime spent developing a type of AI known as deep learning, Hinton stepped back from his role at Google to warn about the existential threats of unchecked AI development.

Since then, there have been ongoing advancements in AI research, technological applications and policy development.

Coleman and Krishnan will tackle these and other topics with guests:

Gillian Hadfield, professor of law and strategic management at the Faculty of Law and the Schwartz Reisman Chair in Technology and Society.
Roger Grosse, associate professor of computer science in the Faculty of Arts & Science and founding member of the Vector Institute.
Christine Allen, professor at the Leslie Dan Faculty of Pharmacy and co-founder and CEO of Intrepid Labs Inc.
Andrew Pinto, a family physician at St. Michael’s Hospital, Unity Health Toronto, and associate professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health.
Nick Frosst, co-founder of Cohere, singer in Good Kid band and a ��˾��ֱ�� computer science and cognitive science alumnus.

“The What Now? AI podcast highlights the incredible researchers at the University of Toronto who are exploring the profound implications of this transformative technology,” says Leah Cowen, ��˾��ֱ��’s vice-president, research and innovation, and strategic initiatives. “These discussions tackle critical questions surrounding AI safety and alignment and its myriad implications across various domains.

“The university is committed to fostering informed discussions that will shape our collective understanding of AI’s role in our society and in our future.”

Coleman says she hopes listeners come away from the podcast feeling more grounded.

Krishnan, for his part, wants the audience to understand “that there is no one group that has ownership” over the technology” and that “the free exchange of ideas and open-source tools encourage people from all disciplines to come see how accessible AI can be, what AI can do for them and how they can advance the discourse in the field.”

��˾��ֱ�� receives $10 million from Ontario government for modernization of high containment facility

Christopher.Sorensen — Mon, 18 Mar 2024 18:15:01 +0000

��˾��ֱ�� receives $10 million from Ontario government for modernization of high containment facility

Christopher.Sorensen Mon, 03/18/2024 - 14:15

Cutline

(photo by Julia Soudat)

Topic

Emerging and Pandemic Infections Consortium

Institutional Strategic Initiatives

Sinai Health

Sunnybrook Health Sciences Centre

Hospital for Sick Children

Health

Subheadline

Renewal of the 20-year-old facility, which allows researchers to study high-risk pathogens, will provide increased capacity to develop new vaccines and therapeutics

Canada’s ability to respond rapidly to emerging infectious diseases is taking a step forward with a $9.9-million investment from the Ontario government to support critical research infrastructure updates to the Toronto High Containment Facility (THCF), which houses the largest containment level 3 lab in the province.

The facility, located at the University of Toronto, is specially equipped to allow researchers to study high-risk pathogens, such as SARS-CoV-2, HIV, tuberculosis and mpox, in a safe and secure way.

Research undertaken at the current facility has advanced our understanding of infectious diseases and strengthened our ability to respond to emerging health threats.

“The THCF strengthens Ontario’s position as a prime location for globally leading companies and top talent to discover and commercialize cutting-edge technologies, while improving our preparedness for future health challenges,” says Leah Cowen, ��˾��ֱ��’s vice-president, research and innovation, and strategic initiatives. “The updated facility will enhance Canada’s health infrastructure and health security, and ensure that Canadian researchers are trained and ready to respond to emerging infectious diseases.”

The provincial funding builds on a previous $35-million investment from the Canada Foundation for Innovation to support efforts to revitalize and expand the THCF and to transform it into the largest academic high-containment research centre in Canada.

The renewal of the 20-year-old facility will provide increased capacity to use state-of-the-art approaches supporting academic research projects as well as collaborative industry-led efforts to develop new vaccines and therapeutics for Canadians. The new provincial investment will also allow the facility to meet the growing demand from industry and public sector partners while maintaining ongoing research projects and an agile responsiveness to future outbreaks.

“The new THCF will allow our researchers to work on the most urgent infectious disease threats, provide greater opportunities to engage with government agencies and industry partners, and allow us to provide unique training opportunities for the next generation of infectious disease leaders, building a strong foundation for Canada’s response to future outbreaks,” says Scott Gray-Owen, academic director of the THCF and a professor of molecular genetics in ��˾��ֱ��’s Temerty Faculty of Medicine.

The provincial support is part of a suite of investments through the Ontario Research Fund and the Early Researcher Awards that also include support for quantum and artificial intelligence projects at ��˾��ֱ��. Support has also been extended to advance an infrastructure renewal of the province’s Advanced Research Computing (ARC) systems, including ��˾��ֱ��’s Niagara ARC supercomputer, used by researchers across the country.

As the only high containment facility of its kind in the Greater Toronto Area, the THCF is a unique asset to the life sciences ecosystem in the region, which is home to 55 per cent of Canada’s pharmaceutical companies. The modernized facility will be able to support greater engagement with industry partners to advance made-in-Ontario therapeutics such as the experimental drug paridiprubart from Markham-based Edesa Biotech, which is currently being tested in a Phase 3 clinical trial to treat acute respiratory distress syndrome, a common complication from COVID-19 or influenza infections.

In addition to industry partners, the THCF has been used by federal and provincial agencies including the Public Health Agency of Canada, Bank of Canada, Rogers Hixon Ontario Human Milk Bank and Ontario Ministry of Natural Resources and Forestry.

The THCF renewal will also be undertaken in collaboration with ��˾��ֱ��’s hospital partners: The Hospital for Sick Children, Sinai Health, Sunnybrook Health Sciences Centre, Unity Health Toronto and University Health Network. Construction of the facility has begun but the university is seeking additional funding to complete the project.

Based at the Temerty Faculty of Medicine, the THCF is the cornerstone of the Emerging and Pandemic Infections Consortium, a ��˾��ֱ�� institutional strategic initiative that brings together the university and Toronto Academic Health Science Network (TAHSN) hospital partners to drive innovative approaches to infectious diseases and prepare for future pandemics. It is also a key infrastructure resource for the Canadian Hub for Health Intelligence and Innovation in Infectious Diseases (HI3) which was established through the Canada Biomedical Research Fund. The hub brings together over 90 partners across several sectors to bolster Canada’s biomanufacturing capacity to ensure a fast and co-ordinated response to future pandemics and infectious threats.

The revitalized THCF will also have the capacity to train more than 100 new highly qualified professionals over a five-year period with industry-relevant skills, including manufacturing practices and vaccine and therapeutics development.

At the beginning of the COVID-19 pandemic, the THCF was the first lab in Canada – and one of the first in the world – to isolate the new coronavirus in March 2020. The facility and its highly trained staff played a key role in accelerating research breakthroughs that guided the pandemic response including, for example, methods to allow safe reuse of personal protective equipment in health-care settings and to ensure safe human milk banking for premature infants.

The THCF was also a core element of EPIC’s mpox rapid research response, housing a biobank of samples from patients with mpox which are being used by researchers to better understand the dynamics of viral shedding and other important questions about the disease.

In addition to a larger physical space, the updated facility will include a state-of-the-art high containment insectary to enable research on mosquito-borne viruses like Chikungunya, dengue, Zika and yellow fever. With its modular design and enhanced safety features, the new facility will also be better positioned to respond to emerging pathogens like highly pathogenic avian influenza.

Mpox DNA can persist in the body for up to four weeks: Study

rahul.kalvapalle — Tue, 12 Mar 2024 20:04:03 +0000

Mpox DNA can persist in the body for up to four weeks: Study

rahul.kalvapalle Tue, 03/12/2024 - 16:04

Cutline

A sign containing information about monkeypox is seen in International Airport Treviso A. Canova, in Treviso, Italy, on Nov. 30, 2022 (photo by Manuel Romano/NurPhoto via Getty Images)

Institutional Strategic Initiatives

Topic

Breaking Research

EPIC